Associate Director, Value Demonstration

Alnylam seeks a motivated and skilled Associate Director of Value Demonstration to join its Value Evidence & Strategy (VESt) group. Working under the direction of a project lead, the successful candidate will focus on the execution of specific RWE research projects from conception through completion, using a variety of real-world data (RWD) sources. This role involves developing study protocols and analysis plans, managing external vendors, and interpreting study results to generate evidence supporting our therapeutic products. The AD does not need to have programming skills but should be able to provide knowledgeable oversight to programming teams and vendors.

This is an hybrid position primarily located at the Cambridge, MA site.

Responsibilities

• Project Execution: Under the guidance of a project lead, translate research ideas and objectives into detailed study protocols, statistical analysis plans, and technical specifications for studies using diverse real-world data (RWD) sources, such as claims data, electronic health records (EHRs), and patient registries.
• Vendor Management: Oversee and provide informed oversight to vendors and contract research organizations (CROs) conducting RWE studies, ensuring timely delivery, adherence to protocols, and scientific rigor.
• Cross-Functional Collaboration: Partner with internal cross-functional teams, including Medical Affairs, VESt Health Economics and Outcomes Research (HEOR), and Epidemiology, to receive guidance on study design, statistical methodologies, and project deliverables.
• Results Interpretation: Interpret, summarize, and present study results to technical and non-technical audiences via study tables, presentations, and reports, ensuring accurate and clear communication of findings.
• Methodological Oversight: Provide informed oversight on methodological approaches used by internal and external programmers, reviewing programming specifications and analytic outputs to ensure quality and validity.
• Quality Assurance: Support cross-functional initiatives to refine internal workflows, procedures, and best practices for RWE activities and ensure studies meet internal quality standards.

Requirements

• Advanced degree (PhD, ScD, DrPH, or Master's) in Epidemiology, Outcomes Research, Health Services Research, Health Economics, Biostatistics, or a related quantitative field.
• 2–3+ years of relevant experience in the pharmaceutical industry or a related consulting environment, with previous experience in executing and managing RWE studies using administrative claims data, EHRs, or registries. A relevant postdoctoral fellowship or internship will also be considered.
• Strong understanding of observational study designs, principles, and concepts.
• Experience overseeing research projects, managing timelines, and collaborating with cross-functional teams.
• Familiarity with interpreting complex statistical analyses, even without direct programming skills.
• Excellent project management, communication, and interpersonal skills, with the ability to effectively manage vendor relationships and internal stakeholder expectations.

Preferred Qualifications

• Experience working in a matrixed, cross-functional organizational structure.
• Familiarity with advanced analytics and machine learning techniques applied to RWD.
• A track record of contributions to scientific publications or presentations in the RWE field.
• Proficiency in statistical programming languages such as R, SAS, or Python.

About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture: Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.