Associate Medical Director of US Evidence Generation

Custom Field 1: 2775

Date: Dec 19, 2025

Location:

Cambridge, MA, US, 02142

Overview

We are seeking a strategic and scientifically driven Associate Medical Director of US Evidence Generation to focus on the development and execution of US real world evidence (RWE) strategies that support the value proposition of Alnylam’s products across the ATTR franchise. This US-centric role will collaborate cross-functionally to generate impactful evidence that informs clinical practice and demonstrates continued value to US HCPs/KOLs, payers and health systems.  As a US evidence generation leader, the candidate will partner with the Value Evidence Strategy team (VESt) to provide medical leadership for strategic projects under their direct responsibility. They will also support the planning and execution of RWE projects conducted by external vendors.

Summary of Key Responsibilities

RWE Strategy Development:

Participate in strategic planning by supporting the development and refinement of the US RWE strategic plan, ensuring alignment with broader Medical Affairs and cross-functional objectives
Identify and prioritize strategic US evidence gaps in close collaboration with cross functional team that includes Medical, Market Access, US Commercial Sales and Marketing
Partner with the US Medical field teams to assess and map RWE generation opportunities and capabilities across KOLs, payers and health systems
Maintain a US KOL database of HCPs and health systems with interest and insights into ATTR evidence generation
Support data-driven refinement of the US RWE strategic plan, content and messages through analysis of key performance indicators (KPIs) related to knowledge, attitudes and practices of US stakeholders through advisory boards, field insight generation and feedback from professional medical associations

Study Design & Execution:

In coordination with the VESt, lead, design, and deliver RWE analyses while serving as a clinical subject matter expert to ensure scientific integrity of conducted RWE research

Cross-Functional Collaboration:

Ensure coordination among matrixed teams including Medical Affairs, Commercial, Publications, Materials Review Boards, Compliance, and external partners to incorporate RWE findings into publications and field materials
Participate in the development of abstracts, manuscripts, and presentations for scientific congresses and peer-reviewed journals

External Engagement:

Lead vendor selection and collaborate with external experts, academic institutions, and data vendors to execute high-quality RWE studies

Data Governance & Compliance:

Ensure all RWE activities comply with relevant Alnylam SOPs, US regulatory, legal, and ethical standards, including data privacy and local guidelines

Qualifications

Advanced degree (PharmD, PhD, MD) with strong preference for candidates with experience in cardiology and/or RWE generation
Minimum of 5 years of experience in medical affairs within the pharmaceutical or biotech industry, including experience in field medical roles, strategy development and evidence generation
Excellent interpersonal, communication, and collaboration skills, with the ability to engage effectively with internal and external stakeholders
Strong scientific acumen, ability to function autonomously, and succinctly communicate with cross-functional stakeholders
Experience managing budgets and external partnerships related to RWE projects
Experience supporting both product launches and lifecycle management with RWE
Entrepreneurial spirit and resourcefulness
Excellent project management skills
Ability to travel as needed to fulfill job responsibilities

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U.S. Pay Range

$190,200.00 - $257,400.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.