Associate Scientist II, Oncology Research - In Vivo

 This role is considered On-Site.

Overview:

The Oncology Research group at Alnylam is seeking a highly motivated Associate Scientist II to join our growing interdisciplinary team aimed at developing RNAi therapeutics against cancer. The successful candidate will be technically skilled in a variety of oncology mouse models with the desire to expand your repertoire. This role requires working closely with all team members to understand the team’s needs to design and conduct diverse experiments, with the flexibility to make changes as needed. The candidate must be motivated, have strong interpersonal and communication skills, and be able to work on a highly collaborative team.

Key responsibilities:

• Engage in investigative RNAi research evaluating siRNA delivery and efficacy to diverse oncology animal models.
• Develop and perform in vivo and ex vivo studies using molecular and biochemical techniques to characterize distribution and activity of a variety of siRNAs.
• Willing to learn new techniques to support in vivo studies including subcutaneous and orthotopic implantations.
• Analyze and interpret data and communicate results to the team.
• Collaborate with team members to progress drug discovery efforts, contributing to a dynamic, exciting culture that embraces teamwork, innovation, and transparency.

Qualifications:

• BS or MS in Animal/Veterinary Sciences, Cell/Molecular Biology, Biochemistry, or related field.
• 1-3 years of research experience in an industrial or academic setting working with mice.
• Experience in mouse handling, dosing, and tissue collection. Specific experience in oncology models strongly preferred.
• Experience in molecular biology techniques including RNA/DNA/protein extraction, qPCR, Western blot, ELISA a plus.
• Proficiency in multiple dosing routes i.e. IP, IV, SC, intratumoral and blood collection (RO or submandibular) preferred.  Intrathecal (IT) and intracerebroventricular (ICV) dosing in mouse a plus.
• Experience in mammalian tissue culture a plus.
• Ability to follow SOPs, execute, analyze, interpret, and troubleshoot experiments.
• Excellent lab technique and the ability to work independently.
• Good documentation of all experimental procedures and results.
• Excellent communicator, team-oriented, and able to handle multiple different experiments at once.

About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture: Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.