Associate Scientist II, Protein Sciences

 This role is considered On-Site.

Overview:

We are seeking an associate scientist-II to join our protein sciences team to contribute to our protein production and conjugation efforts. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. We are searching for enthusiastic, innovative, and highly motivated individuals, with scientific background in protein expression, purification, protein conjugation and analytical techniques, who are comfortable working in a fast-paced entrepreneurial environment. The successful candidate will be part of cross-functional teams including biologists, chemists, and pharmacologists and will contribute to advancing research programs across multiple therapeutic modalities

This lab-based position is onsite and will be located at 675 W. Kendall St. Cambridge, MA 02142

Responsibilities:

• Work closely with the protein sciences team to deliver and validate proteins and protein conjugates at various production scales.
• Design, plan, and perform protein conjugation experiments to support in vitro and in vivo evaluations, contributing to project-related scientific activities with some guidance from team members.
• Utilize UV–Vis spectroscopy and HPLC to analyze, purify, quantify, characterize, and formulate protein conjugates.
• Contribute to the maintenance of laboratory infrastructure and equipment.
• Support group organization, productivity, and expertise through collaboration and idea exchange.
• Meet quality, quantity, and timeline expectations for all assigned projects.
• Support discovery efforts in protein sciences.
• Maintain accurate and complete electronic notebook records.
• Communicate experimental plans and data to multiple cross-functional scientific teams.

Qualifications:

• BS/MS degree in Chemistry, biochemistry, or a related field, with 0–1 years of relevant laboratory experience in a biopharma or academic setting.
• Experience with modern bioconjugation chemistry and analytical techniques.
• Experience with instrumentation such as Agilent and ÄKTA HPLC systems, TFF, and UV–Vis spectrometry.
• Experience with protein and protein conjugate analysis (e.g., affinity chromatography, SEC, RP-HPLC, HIC, IEX, SDS-PAGE, UV–Vis spectroscopy) and label-free binding techniques (SPR and/or BLI) preferred.
• Experience developing new chromatographic methods is a plus.
• Knowledge of protein purification using ÄKTA systems preferred.

About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture: Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.