Associate Scientist II, RNAi Discovery

This role is considered On-Site.

Overview  

The experienced Research Associate Scientist II, with a background in in vitro screening, will be part of our dynamic, fast-paced and interdisciplinary lead development team. Our mission is to advance novel RNAi therapeutic programs from target discovery through lead candidate selection. The Associate Scientist II will be technically skilled in biochemistry or cell biology, and bring a rigorous, analytical approach to research.

Key Responsibilities

• Perform cell culture (iPSCs, primary cells, immortalized cell lines) to support the research needs of the group
• Support lab maintenance including reagent inventory and reagent preparation
• The candidate will perform high-throughput screening of siRNAs using qPCR and a variety of cell-based assays.
• Design and execute in vitro screens and assays to characterize novel siRNA modifications that impact activity or uptake.
• Develop and conduct assays that support in vivo studies (e.g. qPCR, ELISA) for the quantitative analysis of biomarkers or siRNA activity 
• Utilize instrumentation and robotics to aid in high throughput (384-well) screening.
• Adapts well to the changing platform needs, in workflow, projects and other tasks as required by the platform.
• Troubleshoot technical problems and participate in the continuing development and optimization of existing and new protocols.

Qualifications

• A BS in a biological science with at least 2 years of hands-on laboratory experience in cell or molecular biology are required
• Experience in tissue culture and purification/quantification of nucleic acids/protein, including qPCR and ELISA
• Experienced with laboratory automation including liquid handling systems such as Perkin Elmer JANUS or other systems.
• The candidate should be intensely detail oriented, highly motivated, capable of managing multiple projects simultaneously, desire to drive innovation, and willingness to learn
• We particularly seek someone who is detail oriented and who will flourish in a goal-driven team environment under tight deadlines.
• Excellent interpersonal skills with the ability to work well with others in a dynamic and highly collaborative environment.
• Ability to work effectively with others in a collaborative team environment
   

About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture: Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.