Manager, US Benefits

Overview 

The Manager, US Benefits oversees the administration and delivery of Alnylam’s U.S. benefits and leave programs, ensuring accuracy, regulatory compliance, and a high-quality employee experience. This role partners closely with vendors, HR colleagues, and our broker to deliver reliable, employee‑focused service in a fast‑paced environment. This position will report to the Director, US Benefits.

This is a hybrid position and will primarily be based in Cambridge, MA.

Responsibilities

• Manage U.S. leave programs (FMLA, parental, disability) and partner with the Leave/ADA vendor to ensure accurate, compliant, employee‑focused case handling.
• Coordinate closely with People Relations, HRBPs, Payroll, Legal, and vendors to support timely case updates and communication.
• Oversee the day‑to‑day administration of medical, dental, vision, life, disability, HSA/FSA, COBRA, and retirement plans while maintaining service quality.
• Ensure compliance with ERISA, ACA, HIPAA, Section 125, and federal/state requirements, supporting audits, 5500 filings, and nondiscrimination testing.
• Build strong vendor and broker partnerships and act as an escalation point for complex employee inquiries.
• Partner with HRIS to ensure accurate benefits data, testing, system maintenance, and reporting in SAP SuccessFactors.
• Lead annual Open Enrollment planning, communications, testing, data validation, and reconciliation.
• Develop clear, employee‑friendly benefits communications, support wellness initiatives, and provide direct guidance to employees and managers.

Qualifications

• Bachelor’s degree in HR, Business, or related field (or equivalent HR experience).
• 5+ years of U.S. benefits administration experience, including LOA programs exposure.
• Knowledge of ERISA, ACA, HIPAA, and federal/state regulations.
• Experience partnering with third‑party vendors and brokers.
• Experience with SAP SuccessFactors (benefits configuration, data review, workflow coordination).
• Strong communication, relationship‑building, and problem‑solving skills.

#LI-MH1 #LI-Hybrid

U.S. Pay Range

$114,800.00 - $155,300.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.