Postdoctoral Associate

Overview

The Drug Innovation group at Alnylam is seeking a passionate, creative post-doctoral scientist to join our highly interdisciplinary team focused on the advancement of our RNAi Platform and Lead Development efforts through novel approaches towards a deeper mechanistic/structural understanding of RNAi. The successful candidate will have a strong background in oligonucleotide chemistry/synthetic organic chemistry through in-depth hands-on experience in the synthesis and chemical/biophysical characterization of oligonucleotides as well as their conjugates.

This position is onsite and will be primarily located in Cambridge, MA.  

Key Responsibilities

• Synthesize novel nucleosides and  novel ligands, for  oligonucleotides for delivery.
• Synthesize oligonucleosides, purification of oligonucleotides using various chromatography techniques, biophysical studies and nuclease studies
• Collaborate with all team members to synthesize novel oligonucleotides.
• Design and execute the automated synthesis, purification, and analysis of siRNAs with various chemistries and scales using state-of-the-art instrumentation platforms.
• Troubleshoot and perform routine maintenance on critical instrumentation such as automated synthesis platforms, HPLC, and liquid handling robots.
• Work closely with members across various sub teams within RNAi discovery.
• Analyze, organize, and present data at internal meetings.
• Writing experimental details following J.Org. Chem format for patents and publications

Qualifications

• PhD in Chemistry or preferably in Oligonucleotide chemistry, with 0-2 years post-degree experience in an industrial or academic setting.
• Experience in conjugation/bioconjugation chemistry.Solid-phase synthesis techniques with oligonucleotides or peptides is desired.
• Expertise in chromatography purification techniques and troubleshooting.
• Strong laboratory skills and experience with analytical instrumentation such as NMR, HPLC, LC-MS, etc. with the ability to analyze, interpret, and clearly present data.
• The ability to apply experience and  knowledge to a new area of study as well as to thrive in a highly interdisciplinary team environment with excellent oral and written communication skills.
• High degree of flexibility and motivation in a fast-paced work environment.

U.S. Pay Range

$86,500.00 - $117,100.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.