Principal Associate Scientist, Bioanalytical Sciences

Overview

The Bioanalytical Sciences group at Alnylam is seeking a highly motivated Principal Associate Scientist, specializing in molecular PCR-based assays to join our team to help advance novel RNAi therapeutic programs from discovery to the clinic.

This individual will assist in assay optimization and implementation, and support sample analysis across various biological matrices to support early through late stage drug development programs.

This role requires strong attention to detail, with excellent  molecular biology and bench skills, and strong interpersonal skills to successfully collaborate with multiple project teams to provide bioanalytical support. This individual would thrive in a fast-paced, goal-driven environment. This is an exciting opportunity to join a vibrant team and interact with highly motivated scientists across a broad array of disciplinary expertise areas.

This position is onsite and will be primarily located in Cambridge, MA.  

Key Responsibilities

• Implement gene expression assays to inform target engagement in biological matrices using techniques such as RT-qPCR or dPCR.
• Evaluate and implement fit-for-purpose automated RNA extraction methods to improve consistency and performance of gene expression assays.
• In support of program priorities, perform non-GLP sample analysis for emerging and established tissues to support all of Alnylam’s RNAi therapeutic development from early to late stages.
• Design, troubleshoot and interpret experiments.
• Help implement and maintain appropriate procedures and controls to ensure consistent assay performance and reproducible data.
• Maintain meticulous laboratory notebooks, perform data analysis and QC, and communicate results to matrixed teams to support program advancement.
• Collaborate with team members to expand capabilities and improve workflows for molecular analysis and data reporting.

Qualifications

• A Master’s degree (6+ years of relevant industry experience) or Bachelor’s degree (8+ years of relevant industry experience) in molecular biology, biochemistry, chemistry, or relevant field.
• Excellent lab technique and previous experience to perform PCR-based molecular assays, and ability to work independently.
• Has experience with Excel, Word, PowerPoint, and other analytical software (e.g. GraphPad Prism, QuantStudio).
• Detail-oriented and organized with the ability to thrive in a team environment and be comfortable working on and prioritizing multiple projects.
• Has strong interpersonal skills to enable collaboration with cross-functional teams.
• Possesses excellent verbal and written communication skills.
• Experience with biological matrices across preclinical species is strongly preferred.

A quick learner with proven ability to perform in a fast paced working environment.

U.S. Pay Range

$97,300.00 - $137,100.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.