Principal Scientist, Research (Targeted Delivery)

Overview

The Research Department at Alnylam is seeking a Principal Scientist to join a growing team responsible for advancing RNAi therapeutics into the future, by opening up targeted delivery to all tissues. The successful candidate will be a key leader in our ligand discovery efforts, responsible for driving end-to-end ligand discovery projects for novel receptors. This role requires a deep understanding of antigen design, antibody engineering, immunology, and high-throughput screening technologies.

This position is onsite and will be primarily located in Cambridge, MA.

Key Responsibilities

• Lead the design and implement innovative immunization strategies, including the identification, selection, and management of external immunization vendors (CROs).
• Establish and oversee high-throughput B cell screening and selection workflows.
• Develop and integrate a robust Next-Generation Sequencing (NGS) workflow for the rapid identification and analysis of antibody variable region sequences from screening campaigns.
• Drive the design, execution, and automation of high-throughput screening cascades to characterize antibody properties such as affinity, specificity, and function.
• Engineer complex antibody modalities, including Mult specific antibodies, nanobodies, and evaluate novel protein formats.
• Collaborate with cross-functional teams, including protein science, pharmacology, and translational science to ensure project goals are achieved.
• Manage project timelines, resources, and data analysis, and present findings to internal teams and senior leadership.

Qualifications

• Education: PhD in Molecular Biology, Bioengineering, Biochemistry, Cell Biology, or a related field.
• Experience:
• A minimum of 6 years of post-PhD experience in the biopharmaceutical industry, with a primary focus on antibody discovery and engineering.
• Proven track record of successfully leading antibody discovery programs from inception to lead candidate delivery.
• Hands-on experience with single B cell isolation and screening technologies is required; direct experience with the Bruker Beacon platform is required.
• Deep expertise in molecular biology techniques for antibody cloning, expression, and sequence analysis, including extensive experience with NGS library preparation and data interpretation.
• Demonstrated experience developing and running high-throughput, automated screening assays.
• Experience with managing external research collaborations and CROs for immunization and discovery campaigns.
• Track record of successfully managing and developing research scientists preferred

#LI-JR1

U.S. Pay Range

$147,200.00 - $220,800.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.