Scientist, mRNA

Overview

The Delivery Sciences team at Alnylam is seeking a Scientist to contribute to our ligand discovery efforts for expanding RNAi delivery to all tissues. The successful candidate will help drive ligand discovery and selection efforts through design and characterization of mRNA formulations. This role requires a strong background in molecular biology and biochemistry, along with hands-on expertise in designing and optimizing stabilized mRNA for in vivo applications. The individual will need excellent organization and communication skills to work collaboratively across multiple groups in the research organization.

This position is onsite and will be primarily located in Cambridge, MA.  

Key Responsibilities

• Design mRNA compositions to drive high, persistent in vivo expression of target proteins resulting in robust immune responses in animal models
• Systematically optimize mRNA designs to enhance translation efficiency, structural stability, and extended in-cell lifetime.
• Implement optimized mRNA designs for binder discovery in collaboration with teams across research
• Prepare clear and well-structured experimental reports and data presentations
• Contribute to a cross-functional team of biologists, chemists, and pharmacologists to drive the strategic direction of research programs across multiple therapeutic modalities

Qualifications

• PhD in Molecular Biology and biochemistry with 1-3 years relevant industry/academic experience
• Expertise in mRNA design, optimization, preparation and characterization
• Demonstrated proficiency in mRNA antigen design and immunization strategies for binder discovery
• Hands-on experience in self-amplifying RNA is preferred
• Experience in NGS library preparation and bioinformatic analysis of high throughput sequencing data will be a plus
• Strong experimental design/execution, rigorous data analysis, diligent record keeping (ELN, inventory management), and the ability to manage multiple projects in parallel are required

Excellent communication skills (both written and oral) are essential.

U.S. Pay Range

$110,400.00 - $165,600.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.