Senior Associate Scientist, Bioinformatics

This position is onsite and will be primarily located at 675 W Kendall St Cambridge MA.

Overview:

With six commercially approved RNAi therapeutics, Alnylam is at the forefront of gene silencing. Our success is built upon a rational, sequence-based approach to drug design driven by predictive models and high-throughput data generation. As a bioinformatician analyzing and communicating the results from large NGS datasets to Alnylam Scientists, you will have an opportunity to be at the cutting edge of RNA biology and learn from a talented interdisciplinary team of data scientists, bioinformaticians, and molecular biologists.  Due to the sequence-based design of our drugs and the central role of transcriptomics, you will have a front-row experience to our rational, rapid, and efficient drug development pipeline. You will have the opportunity to evaluate and develop pipelines for new sequencing-based technologies as a key part of a bioinformatics team that is helping to bring a whole new therapeutic modality to patients across a wide variety of tissues and disease contexts.

Responsibilities:

• Run and develop proprietary Next Generation Sequencing analysis pipelines for short- and long-read technologies.
• Communicate results of computational analyses to interdisciplinary teams of scientists.
• Investigate state-of-the art statistical methods and ‘omics tools for novel sequencing technologies (e.g. RNA modification measures, proteogenomics).
• Assist in the interpretation of results from complex scientific experiments.
• Professionally maintain code in a version-controlled repository.
• Contribute to our data science culture.

Requirements:

• M.S. in a quantitative discipline, or B.S. (2+ years) with equivalent professional experience.
• Coding capability in R and Python.
• Prior experience with the analysis of omics-based biological datasets is essential; familiarity with NGS and differential expression analysis tools preferred.
• Experience with statistical methods and comfort reading and understanding scientific publications is preferred.
• A drive to learn and understand new sequencing-based technologies, and to develop and troubleshoot downstream analysis pipelines.
• Comfort working with Unix systems and cloud-based computing environments and tools (e.g. AWS, docker).
• Knowledge of, or an interest in learning, the fundamentals of RNAi biology.
• Experience communicating and presenting scientific results, as well as collaborating closely with colleagues with varied skill sets.

U.S. Pay Range

$76,300.00 - $114,500.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.