Senior Associate Scientist, Oncology Research - In Vivo

Overview:

The Oncology Research group at Alnylam is seeking a highly motivated Senior Associate Scientist to join our growing interdisciplinary team aimed at developing RNAi therapeutics against cancer. The successful candidate will have hands-on experience  working with advanced in vivo oncology models, including subcutaneous xenograft, and syngeneic models with the desire to learn additional models.  In this laboratory-based position, you will design, execute, and interpret in vivo experiments to evaluate the efficacy and mechanisms of action of oncology drug candidates. This role requires collaborating closely with team members  to ensure timely delivery and communication of program data with the flexibility to make changes as needed. The candidate must be motivated, have strong interpersonal and communication skills, and be able to work on a highly collaborative team.

Responsibilities:

• Engage in investigative RNAi research evaluating siRNA delivery and efficacy to diverse oncology animal models.
• Develop and perform in vivo and ex vivo studies using molecular and biochemical techniques to characterize distribution and activity of a variety of siRNAs.
• Routine tasks would include cancer cell line culture, in vivo efficacy, and PK/PD studies as well as processing harvested tissue for ex vivo analyses.
• Analyze and interpret data and communicate results to the team.
• Collaborate with team members to progress drug discovery efforts, contributing to a dynamic, exciting culture that embraces teamwork, innovation, and transparency.

Qualifications:

• BS or MS in Animal/Veterinary Sciences, Cell/Molecular Biology, Biochemistry, or related field.
• 3-5 years of research experience in industry  conducting in vivo pharmacology studies using mouse tumor models is essential.
• Expertise in mouse handling, dosing, subcutaneous and orthotopic tumor implantation, and tissue harvesting and collection.
• Experience working with syngeneic and immune-compromised mice required.
• Direct experience monitoring tumor growth using IVIS or Lago and software analysis required.
• Proficiency in multiple dosing routes i.e. IP, IV, SC, intratumoral and blood collection (RO or submandibular) required.
• Experience in tumor cell line tissue culture required.
• Stereotaxic procedures, intrathecal (IT), and intracerebroventricular (ICV) dosing in mice a plus.
• Experience in molecular biology techniques including RNA/DNA/protein extraction, qPCR, Western blot, ELISA a plus.
• Basic understanding of standard cancer therapeutics and immuno-oncology a plus.
• Experience using Prism, IVIS or Lago software analysis, Excel required.
• Ability to follow SOPs, execute, analyze, interpret, and troubleshoot experiments.
• Excellent lab technique and the ability to work independently.
• Good documentation of all experimental procedures and results in an ELN.
• Excellent communicator, team-oriented, and able to handle multiple different projects/experiments at once.

U.S. Pay Range

$76,300.00 - $114,500.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.