Senior Scientist, Next Wave, Target Discovery & Validation

Overview

The Research Department at Alnylam is seeking a highly motivated and creative scientist to join our Next Wave Target Discovery and Validation team. Our mission is to discover and experimentally validate novel RNAi therapeutics targets in disease areas with high unmet need. This position offers a unique opportunity to lead and shape the strategical direction of the next generation of RNAi medicine. With breadth responsibilities spanning from target discovery throughout early clinical development. You will be collaborating closely with interdisciplinary teams of colleagues from Alnylam human genetics, translational science, RNAi platform, delivery sciences, clinical development and new product commercialization.

This is an on-site position located in Cambridge, MA.

Summary of Key Responsibilities

• Identify and prioritize novel RNAi targets via human genetics, literature review, systems biology and experimental approaches
• Design and execute in vitro and in vivo studies to validate candidate targets and elucidate the underlying mechanisms of action
• Analyze, interpret and present scientific data in internal meetings and contribute to strategic planning discussions
• Initiate and lead the exploration on new areas of interest for RNAi therapeutics
• Lead collaboration with external partners, including partners, CROs and academic institutions; including setting project strategy, design, planning, data interpretation and decision making
• Collaborate and communicate results with key stakeholders throughout the organization
• Manage and mentor junior scientists and associate scientists

Qualifications

• PhD in biology and biomedical science related field with >6 years postgraduate experience
• 3+ years of biotech/pharma industry experience is preferred
• The applicant must have strong scientific curiosity with a flexible mindset and passionate about learning and applying knowledge to new areas
• Proven expertise in developing and characterizing in vitro, ex vivo, and in vivo models, with a strong understanding of disease biology, pathogenesis and mechanisms of action
• Familiarity with the application of genetics and genomics approaches (e.g., GWAS) to inform biological understanding is a strong plus
• Experience in the field of physiology, muscle biology, cardiology and cardiometabolic diseases is strongly encouraged to apply
• Thrive in a fast-paced team environment and possess excellent communication skills (both written and oral).

About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture: Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.