Sr. Director, HRBP Commercial

Custom Field 1: 2616

Date: Nov 17, 2025

Location:

Cambridge, MA, US, 02142

Overview:

Alnylam is seeking a progressive, dynamic, business-focused HR Business Partner to support our US Commercial organization. Reporting to the VP HR, Commercial, this HR Business Partner will play a key role in delivering on the people and organizational strategy in partnership with our US Commercial leadership team. This is an exciting time to join Alnylam in its mission to bring a new class of medicines to market as part of a well-respected and highly effective HR team.

Responsibilities:

Partner with senior leaders to drive business results and evolve the organization in a sustainable and effective way.
Shape and execute robust people and culture strategies and support our Company wide transformation.
Improve leadership and team effectiveness.
Drive organization development and design.
In partnership with Talent Acquisition, develop workforce plans to recruit top talent.

Strategic Partner:

Lead HR strategy and execution. Ensure alignment between business imperatives and the HR strategy and objectives.
Partner with senior leaders to determine effective HR solutions to facilitate organizational growth and effectiveness.

Coach and Develop:

Act as strategic advisor on all aspects of people and leadership including development plans, change management, team effectiveness, employee engagement.

HR Lifecycle:

Run annual HR processes (i.e. compensation planning, performance management, talent review, workforce planning etc.).
Lead one or more HR projects.

Qualifications:

Bachelor's degree required.
Minimum 12 years’ experience in HR, including senior level HR Business Partner roles, required. Experience in HR Centers of Excellence (i.e., Talent Acquisition, Talent Management, Compensation, Employee Relations) preferred.
Successful track record of managing multiple projects in a fast-paced environment.
Experience working in a global and fully integrated Company required.
Experience in life sciences required.

U.S. Pay Range

$225,300.00 - $304,800.00

The pay range reflects the hourly wage range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. Pay range does not include shift differential pay if applicable. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.