Sr. Manager, US Commercial Revenue

Overview:

Alnylam Pharmaceuticals is seeking a US TTR Revenue Senior Manager to join the US TTR Finance organization in one of Cambridge’s most innovative, publicly traded biotech companies focused on translating the science of siRNA into human therapies.

This is an exciting opportunity to play a critical role in delivering accurate, timely, and insightful revenue reporting and analysis to support strategic decision-making. The ideal candidate is highly analytical, curious, and passionate about uncovering trends and driving automation to improve efficiency and data integrity. This position offers significant visibility within the organization and frequent interaction with senior leadership.

This role reports directly to the Senior Director, US TTR Finance and interfaces regularly with the Associate Director of Revenue, Manager of Opex, and the extended US TTR team. The position is hybrid and primarily based in Cambridge, MA.

Responsibilities:

Revenue Reporting & Analysis

• Manage daily sales reporting across multiple dimensions (SF, demand, ex-factory, and revenue).
• Produce weekly demand-based new patient add reports for leadership.
• Maintain and enhance the weekly CM patient model to enable better near term forecasting.
• Track detailed daily unit volume (including across distributor, region, source of business, payer, and other dimensions) to support enhanced forecast modeling.
• Deliver accurate reporting and provide clear explanations of emerging trends.
• Cross-train on other responsibilities across US TTR finance team; support some opex tracking as needed.

Month-End Close & Data Management

• Support month-end close activities, including demand tie-out and master file maintenance.
• Ensure data integrity across revenue processes through rigorous checks and reconciliations.

Process Improvement & Automation

• Identify opportunities to streamline and automate reporting processes, including potential migration of some reports to automated dashboards.
• Implement tools and solutions that improve efficiency and reduce manual effort.

Qualifications:

• Bachelor’s degree in Finance, Accounting, Economics, or related field.
• 7-10 years of relevant experience in revenue management, FP&A, or similar analytical roles.
• Advanced proficiency in MS Excel; experience with data visualization tools (e.g. Power BI) strongly preferred.
• Strong technical aptitude and ability to work with complex datasets.
• Excellent analytical, problem-solving, and communication skills.
• Ability to manage multiple priorities and deliver under tight deadlines.
• Self-motivated and detail-oriented with a continuous improvement mindset.

U.S. Pay Range

$138,600.00 - $187,500.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

About Alnylam

We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.