Vice President, Early Commercial Strategy

Overview:

The Vice President of Early Commercial Strategy is a key senior function that will report to the SVP of Value & Pipeline commercialization.  This role requires a visionary and results-drive leader to lead the strategic development and commercialization planning for our future product portfolio. This senior executive will play a critical role in shaping the company’s long-term growth by identifying, evaluating, and prioritizing new product opportunities across the development pipeline and external innovation landscape.

This position is hybrid and will be primarily located at Alnylam headquarters in Cambridge, MA.

Key Responsibilities:

Strategic Product Planning:

• Lead the end-to-end strategy for new products from early-stage development through commercialization readiness.
• Develop Target Product Profiles (TPPs), value propositions, and differentiation strategies in collaboration with R&D, Clinical, and Commercial teams.
• Drive disease area strategy, market segmentation, and product positioning based on unmet needs, competitive landscape, and evolving science.

Cross-functional Leadership:

• Collaborate closely with R&D, Regulatory, Medical Affairs, Business Development, and Marketing to ensure alignment on product vision and execution.
• Act as the commercial voice in development-stage governance forums and joint decision-making committees.

Market & Competitive Intelligence:

• Assess emerging trends, market dynamics, and competitive activity to inform pipeline decisions and portfolio prioritization.
• Evaluate strategic implications of evolving regulatory, pricing, and access landscapes globally.

Portfolio & Lifecycle Management:

• Contribute to portfolio optimization decisions including asset advancement, prioritization, or termination.
• Develop strategic lifecycle management plans to extend product value and market impact. 

External Innovation & Partnerships:

• Support business development in identifying and assessing external innovation opportunities.
• Collaborate on due diligence and integration strategies for in-licensed or acquired assets.

Team Leadership

• Build  / develop high performing team with the right capabilities to support Alnylam’s next phase of growth

Qualifications

• BA / BS degree required; advanced scientific or business degree preferred
• 15+ years of biopharmaceutical or related experience, including global / international team responsibilities
• Experience in drug development and global product registration is a plus.
• Deep understanding of, and experience with, global and regional / country  product commercialization in highly competitive markets. US market experience is a must.
• Ability to influence cross-functionally and drive alignment within the team, with peers and with senior management. Demonstrable level of executive presence.
• Ability to operate at both the strategic and tactical level, with ability to seamlessly move between both perspectives.
• Proactive “hands-on” individual with collaborative orientation, who manages matrix teams effectively, is very self-motivated and can smoothly establish and sustain strong working relationships within both internal stakeholders
• Decisive as well as collaborative. Can flex when needed and pursues data-driven decisions infuses with strong patient / physician / market-centricity

About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture: Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as the #1 Large Employer by Boston Globe Top Places to Work in 2023 for the third consecutive year, one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients. Qualified applicants will receive consideration for employment without regard to their race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, ethnicity, marital status, protected veteran status, disability, or any other characteristics prohibited by law.