Manager, Clinical Operations

This role is considered Hybrid.

1982: Manager, Clinical Operations
Location: Maidenhead, UK – Hybrid

Join Alnylam – Pioneering the Future of RNAi Medicine!
At Alnylam, we were founded in 2002 with a bold vision: to revolutionize medicine through RNA interference (RNAi). Today, that mission drives us forward as we develop ground-breaking treatments for rare genetic, cardio-metabolic, hepatic infectious, and central nervous system diseases with significant unmet needs.

Our success speaks for itself—ONPATTRO™ (patisiran) became the first FDA-approved RNAi therapeutic, and we’re advancing three more investigational medicines in late-stage development. As a company recognized by The Boston Globe as a Top Place to Work four years running, we’re committed to fostering an environment where innovation thrives.

About the Role – Lead Global Clinical Trials That Change Lives
In this role, you’ll help lead global clinical trials for a high-profile asset, ensuring they run with precision, impact, and speed. Our dynamic, close-knit global team blends hard work with fun, and we’re looking for someone who thrives in fast-paced environments, challenges the status quo, and brings fresh ideas to the table.

What You’ll Do

• Lead and oversee global clinical trial operations, managing cross-functional teams, CROs, and vendors.
• Shape clinical strategy from protocol design to study execution, ensuring trials are on time and within budget.
• Drive patient recruitment strategies and engage with Key Opinion Leaders.
• Optimize vendor partnerships, track KPIs, and manage study timelines, budgets, and risk mitigation plans.
• Collaborate cross-functionally with Regulatory, Medical Affairs, Supply Operations, and more.

Essential Skills & Experience

• Bachelor's Degree (or equivalent) is required. An advanced degree in a scientific and/or business/finance discipline is preferred
• 5+ years of clinical research experience, including global late-stage (Phase 2-4) trials.
• 2-4+ years in clinical project management, ideally with rare diseases or hard-to-recruit populations.
• Experience with protocol, ICF, CRF, CSR development and review
• Strong regulatory knowledge (GCPs), vendor management expertise, and experience leading multinational studies.
• Experience in novel clinical drug development
• Exceptional organizational, problem-solving, and leadership skills.

Desirable Skills & Experience

• Phase 3 oversight experience
• Exposure to leadership meetings and strategy development
• EU CTR experience
• Rare disease or hard to recruit population experience

Personal Attributes

• Exceptional organizational skills and the ability to deal with competing priorities, alongside strong reasoning and problem-solving ability
• Excellent communication (written and verbal) and presentation skills along with leadership qualities
• Ability to apply project management best practices to programs

Here, you’ll shape the future of medicine, work alongside top-tier experts, and be part of a culture that values collaboration, impact, and innovation.

Ready to make a difference? Join us.

Next Steps
The closing date of this vacancy is Sunday, 20th April however, we welcome your application as soon as possible.

About Alnylam: Alnylam Pharmaceuticals (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and more prevalent diseases. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach to treating diseases at their genetic source by “interfering” with mRNA that cause or contribute to disease. Since our founding in 2002, Alnylam has led the RNAi Revolution and continues to turn scientific possibility into reality.

Our culture: Our people-first culture is guided by our core values: fiercely innovative, open culture, purposeful urgency, passion for excellence, and commitment to people, and these values influence how we work and the business decisions we make. Thanks to feedback from our employees over the years, we’ve been fortunate to be named a top employer around the world. Alnylam is extremely proud to have been recognized as one of Science Magazine’s Top Biopharma Employers, one of America's Most Responsible Companies for 2024 by Newsweek, a Fast Company Best Workplace for Innovators, and a Great Place to Work in Canada, France, Italy, Spain, Switzerland, and UK – among others.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. We are dedicated to building an environment where employees can feel that they belong, can bring their authentic selves to work, and achieve to their full potential. By empowering employees to embrace their unique differences at work, our business grows stronger with advanced and original thinking, allowing us to bring groundbreaking medicines to patients.